Is There A Direct Relationship In Spike Glycoprotein Percent Identity, Peptide Count, and Mortality Rate Between Daughter Human Coronavirus Strains And The “Parent” (HCoV-229E)?
Spike Glycoprotein Relationships Between Daughter Human Coronavirus Strains And “Parent” (HCoV-229E)? Applied Technology High School Umm Al Quwain Campus, UAE Ebrahim Waleed Ebrahim Ahmed Al Mansoori Hamdan Mohamed Khalfan Khairi Al Noobi Al Hammadi Mohammed Abdalla Rashid Abdalla Rashid Abstract In this investigation, we sought to identify the following relationships between the Human Coronavirus HCoV-229E strain (“Parent”) and subsequent daughter strains (HCoV-NL63, HCoV- HKU1, HCoV-OC43, MERS-CoV, SARS-CoV, and SARS-CoV2) in their Spike Glycoproteins: Percent Identity, Peptide Differences, and Mortality Rate. We also aimed to propose a possible reason as to why a given strain of Human Coronavirus is more fatal than others. To compare percent identity between each daughter strain’s Spike glycoprotein sequence to that of the “Parent”, we used an online amino acid sequence alignment database called Protein BLAST. To identify peptide-count differences between Parent and daug...